Genomyx Decimate AMPlified

Product Description

The Evolution of Fat Loss

“The power to wage war is the power to wage war successfully.” – Charles Evans Hughes

There’s a strategy to taking your body back from the hordes of adipocytes, from the toll a few unwanted pounds may take. To banish, to DECIMATE, these invasive cells and the psychological and physical effects they impose.
As advocates of general health, we understand that a war must be waged to bring the balance back, to allow you to be and perform at your best.
And to wage this war successfully, we call for maximum adipose tissue eradication…

The market for fat loss products is a bit over whelming at times and it can be hard to decipher whats good and worth it or whats just hype. Most products rely heavily on stimulants to give the users perceptions of an effective product and while it may be great for appetite and energy they tend to not do much for actual fat loss. With that in mind Genomyx set out to make a stimulant free fat loss aid that could truly help accelerate you on your way to leanness

Overview of ingredients and function

• Alpha Yohimbine (Rauwolscine)Extracted from yohimbe bark, yohimbine has been a popular fat loss staple with bodybuilders for years due to its antagonism of alpha-2 adrenoreceptors (1,2,3,4). It induces lipid mobilization through NE activity without an elevating effect on epinephrine, which makes it a great stackable fat loss candidate (3,5). Although it can potentiate post-prandial insulin response (yet no insulinogenic effect is seen without food), yohimbine also has the ability to downregulate lipoprotein lipase activity in adipose tissue, which counteracts any anti-lypolytic activity of insulin (5,6).

  Some people have found the side effects of mixed isomer yohimbine make effective dosing tough to tolerate. The most common complaints involve elevated blood pressure and a “tweaked” feeling, especially when combined with other stimulants. This is where Alpha Yohimbine, a.k.a. rauwolscine comes in. Standard yohimbine is a mixture of alpha and beta isomers, whereas rauwolscine is only the alpha, which eliminates the undesired side effects while actually increasing fat loss activity due to better receptor binding affinity and increased central dopaminergic activity.

  It also has a fairly pronounced aphrodisiac effect in most users, which, in males, couples nicely with its ability to cause vasodilation, aka increased blood flow to the “extremities”, in part through 5-HT2b antagonism. And if that weren’t enough, it has also been shown to increase ejaculatory volume, which you’ll appreciate after you lose enough body fat for someone else to finally find you attractive (7).

  Interestingly, a-Yohimbine binds to human alpha-2 adrenoreceptors with a higher affinity than it does in rodents, which make the slew of rodent studies even more impressive (8).

  Rounding off the alpha-Y benefits, it also offers some pretty potent mental stimulation and mood elevating effects by modulating dopamine and serotonin, all while suppressing appetite, making pissed off and hungry dieting a thing of the past (9,10,11).

  Alpha Yohimbine(Rauwolscine) Review:

  • Increase Lipolysis through NE modulation
  • Prevent halting of lipolysis through a2 antagonism
  • Improves blood flow to the extremities
  • Boosts mood and suppresses appetite through dopamine and serotonin modulation

   

  Raspberry Ketones

  Structurally similar to capsaicin and synephrine, Raspberry Ketones (RK’s) display a lipolytic effect through the activation of the transient receptor potential vanilloid type 1 (TRPV1) protein located throughout the central and peripheral nervous system in the body.

  TRPV1 modulation has been a hot area of research lately, implicated with regards to numerous health and body composition benefits. Researchers from Current Pharmaceutical Design reported that activation of TRPV1 receptors in the brain can potentially alleviate symptoms of pain and anxiety (12). A team out of Brown University found that TRPV1 activation may be an effective angle at treating depression through interneuron formulation, stating “TRPV1 channel activation is necessary and sufficient to trigger long-term synaptic depression (LTD)” (13).

  Through modulation of NE and hormone sensitive lipase, RK’s appear to be a powerhouse for encouraging fat loss and prevention of fat gain. When mice were fed a high fat diet, RK’s prevented visceral and liver fat accumulation as well as reversing the gain in previously obese mice (14). Recently liver fat has been implicated in metabolic disturbances to an even greater degree than the previous villain, visceral fat, so this is a benefit of great magnitude for overall health (15).

  In another study, after 120 days of a TRPV1 agonist researchers concluded adipogenisis and obesity were prevented by activation of TRPV1 channels (16). And if anybody tries to tell you RK is an anti-androgen, yes, it is a weak anti-androgen in breast cancer cell lines, in vitro, which is a good thing (17). Antiandrogenic activity in muscle tissue has never been demonstrated in the research. Numerous compounds are antiandrogenic in certain tissues (and beneficially so, such as milk thistle and the prostate) yet do not display this activity in skeletal muscle (18,19).

   Raspberry Ketones Review:

  • Increases lipolysis
  • Reduced diet induced weight gain
  • Inhibits adipogensis

   

  Capsaicin

  Capsaicin is part of the vanilloid family, and is the phytochemical in chili peppers that causes them to be hot. Current research and user feedback both strongly support capsaicin for fat loss, working through increased channel expression of TRPV1 (like piperine and raspberry ketones), AMPK activation, and NE elevation (20,21).

  A 2008 study published in the journal Life Sciences showed that when rats were fed capsaicin in their diet (the same percentage of energy intake that average rural Thai folk consume daily, at 0.014%), they showed a 29% reduction in visceral fat with no change in caloric intake (22).

  Capsaicin is a novel compound in that it not only promotes fat loss, but it also helps to prevent fat cells from forming in the first place (from a process known as preadipocyte differentiation and proliferation). It has also been shown to inhibit the expression of PPARgamma (which regulates fatty acid storage) and upregulate adiponectin, an adipokine of which higher levels are associated with leanness (22). In concert with the previous study on preventing fat gain, a 2007 study out of China showed that giving mice capsaicin for 120 days on a high fat diet prevented fat gain, compared to the same capsaicin protocol with a high fat diet given to TRPV1 knockout mice. “Knockout” is a science nerd term for genetically altering a subject to eliminate or emphasize a variable, in this case by removing the TRPV1 receptor, which just gives us more evidence that capsaicin works (at least in part) through TRPV1 regulation (23). Another recent study along these lines from the Journal of Clinical Nutrition demonstrated that capsaicin (in conjunction with green tea) reduced energy intake during a positive energy balance, while subjects in a negative energy balance noticed less hunger and more satiety (21).

  The Journal of Nutrition and Metabolism recently published a study showing multiple benefits in humans from oral capsaicin administration, including an increase in VO2, increase in plasma NE, decrease in serum FFA’s (meaning they were oxidized), blunted accumulation of blood lactate and a shift in substrate utilization towards fat at rest (21).

  Capsaicin may also be a great tool to help prevent fat re-gain after getting down to goal body fat levels. In a 2003 study published in the British Journal of Nutrition, subjects were given capsaicin after a four week very low calorie diet to see if it prevented fat re-gain after losing 5-10% of bodyweight. The researchers determined that “capsaicin treatment caused sustained fat oxidation during weight maintenance compared with placebo” (24).

  Capsaicin Review:

  • Increases fat loss through AMPK activation and elevating NE
  • Reduces diet induced weight gain
  • Controls appetite and improves satiety
  • Inhibits PPARgamma and upregulates adiponecton
  • Shifts substrate utilization towards fatty acids at rest

   

  Green Coffee Bean extract

  Before coffee beans are roasted to the dark brown color we’re used to seeing, they’re typically a green or brownish green. In this state, they offer an unadulterated source of chlorogenic and caffeic acid, which may be quite beneficial in the quest to lose body fat.

  Shimoda, et al. found green coffee bean extract (GCBE) to reduce body weight and visceral fat in mice, and concluded that “GCBE is possibly effective against weight gain and fat accumulation by inhibition of fat absorption and activation of fat metabolism in the liver” (25). The same study found that GCBE was capable of reducing hepatic triglycerides, which when elevated can contribute to significant metabolic damage.

  Chlorogenic acid contains ferulic acid, which has been shown to act on nitric oxide from the vascular endothelium. In a 2004 study conducted in Japan, the researchers put subjects with a reduced vasodilation response on either a GCBE or a placebo drink for 4 months and measured changes. After one month, measures of vasoreactivity increased, and continued to improve over the course of the whole four months of testing. The GCBE subjects also had a significant decrease in plasma homocysteine compared with pre-ingestion levels (26).

  Chlorogenic and caffeic acids have been shown to have a significant and favorable impact on adipokine modulation. A 2010 study published in the American Journal of Clinical Nutrition showed that the two acids decreased interleukin-18 and isoprostane while elevating adiponectin. For those of you not quite up to speed on your adipokines, here’s a quick description:

   

  Interleukin-18

  A pro-inflammatory cytokine with the ability to induce severe inflammatory reactions in the body. Like most cytokines it has important functions (in this case, combating intracellular bacteria), but being pro-inflammatory, it’s something we definitely don’t want getting too high (27). The above study showed a decrease in interleukin-18 by 8%.

  Isoprostane

  A prostaglandin like compound produced as a byproduct when free-radicals cause peroxidation of essential fatty acids (28). This is marker of bad things happening in the body, so when it decreases that means you’ve effectively reduced EFA peroxidation, which is a good thing. The above study showed a decrease in isoprostane levels by 16%.

  Adiponectin

  As the outlier of adipokines, levels of adiponectin are inversely related to body fat levels in adults. It’s anti-

  inflammatory, anti-atherogenic, it helps repair glucose metabolism and insulin signaling, and does a whole

  host of other beneficial things in the body, some that aren’t even fully understood yet (29). The above

  study showed an increase in adiponectin by 6%.

  Aside from that, these coffee compounds also improved the LDL:HDL cholesterol ratio and caused a decrease in overall inflammation, which was further replicated in a 2006 study demonstrating a pain reduction effect in animal testing due to the anti-inflammatory effect (30).

   Green Coffee Bean Extract Review:

  • Inhibits fat absorption
  • Increases fat metabolism in liver
  • Reduces diet induced weight gain
  • Improves cholesterol ratio
  • Improves glucose metabolism and insulin signaling

   

   

  Forskolin

  Forskolin is a diterpine extracted from the plant choleus forskohlii. It is has long been known for its ability to directly increase  cyclic adenosine monophosphate(cAMP) through activating adenylate cyclase.(31) cAMP is a second messenger important to many biological functions including lipolysis, the process in which fats are consumed for energy(32). Activating this process can ensure that a larger percent of your weight loss will be attributed to adipose, not muscle.  They’re many other downstream effects of elevated cAMP levels that can benefit athletes such as a relaxation of arteries and smooth muscles, improved insulin secretion and thyroid function.(35,36,37)

  In one human study in overweight men an oral dose of 250mg(of 10% extract Forskolin) given twice daily over a 12-week period had significant(p<0.05) effects on body fat percentage, bone density and free testosterone as well as a trend towards an increase in lean body mass.(33) The increase in testosterone from baseline is only marginally significant, but when compared to the placebo group where a decline in testosterone was noted it’s much more apparent how big an impact this can have. It is very typical to see a decline in testosterone levels in accordance with more aggressive weight loss regiments (34). Maintaining optimal testosterone levels while dieting is an important factor in potential progress.

  Forskolin Review:

  • Increases cAMP levels
  • Increases lipolysis
  • Maintains testosterone levels on hypocaloric diets

   Decimate Overview:

  Decimate is designed for any individual looking to reduce body fat without the crazy side effects of most stimulant laden fat burners. Decimate can be stacked with many other products and will greatly accelerate you on your way to the leaner more muscular physique you’ve been working for.

  Decimate Mechanisms of Action:

  • Increase Lipolysis
  • Prevent halting of lipolysis through a2 antagonism
  • Improves blood flow to the extremities
  • Boosts mood and suppresses appetite through dopamine and serotonin modulation
  • Reduced diet induced weight gain
  • Inhibits adipogensis
  • Inhibits fat absorption
  • Increases fat metabolism in liver
  • Improves cholesterol ratio
  • Improves glucose metabolism and insulin signaling
  • Increases cAMP levels
  • Maintains testosterone levels on hypocaloric diets
  • Increases fat loss through AMPK activation and elevating NE
  • Controls appetite and improves satiety
  • Inhibits PPARgamma and upregulates adiponecton